Combining peyote with monoamine oxidase inhibitors (MAOIs)—usually to amplify the effects—is likely to increase nausea and may even be dangerous. In fact, the nausea that tends to arise from taking peyote alone may have something to do with the presence of naturally occurring MAOIs like tyramine.  
 Alliance for Human Research Protection. (2015, Jan 18). 1947–1953: Navy’s Project CHATTER tested drugs for interrogation. Retrieved from http://ahrp.org/1947-1953-navys-project-chatter-tested-drugs-for-interrogation/.
 Psychoactive Substances Act 2016 [UK]. Retrieved from https://services.parliament.uk/bills/2015-16/psychoactivesubstances.html.
Peyote buttons appear to retain mescaline for an exceptionally long time—potentially even thousands of years!  . The key (once thoroughly dried) is proper storage in cool, dark, dry conditions, ideally in an airtight container.
Later, in 1947, having learned of Nazi experiments exploring mescaline as a possible “truth serum,” the US government began its own secretive program along the same lines, codenamed “Project CHATTER.”  This project later gave up on mescaline and turned its attention to LSD, but was ultimately deemed a failure in 1953.
 PsychonautWiki. (2018, Feb 11). MAOI – Interactions. Retrieved from https://psychonautwiki.org/wiki/MAOI#Interactions.
Google searches, meanwhile, have remained fairly steady for peyote since 2004—although searches for mescaline have decreased. Searches for peyote did reach an all-time high in December 2014 (and again in May 2015) but this was most likely in relation to its appearance in the video game Grand Theft Auto V. Unsurprisingly, most Google searches for peyote come from Mexico, the United States, and Canada. (The popularity of the search term in Uruguay likely has more to do with the Uruguayan band El Peyote Asesino.)
 Jones, P.N. (2007). The American Indian Church and its sacramental use of peyote: A review for professionals in the mental-health arena. Mental Health, Religion & Culture, 8(4):277-290. doi:10.1080/13674670412331304348.
 Halpern, J.H., Sherwood, A.R., Hudson, J.I., Yurgelun-Todd, D., Pope, H.G. Jr. (2005). Psychological and cognitive effects of long-term peyote use among Native Americans. Biological Psychiatry, 58(8):624-31. doi:10.1016/j.biopsych.2005.06.038.
What's a peyote cactus? What are peyote buttons? What is a peyote trip like? Our Essential Guide covers all you need to know about this natural psychedelic.