CBD Oil Side Effects On Liver

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‘Hopefully it stands up — because otherwise, we’re kind of all owed an explanation for why this was pushed on us.’ The liver is involved in a wide range of critical physiological functions. This article explores the ways CBD can affect our liver.

64 million Americans have tried CBD and now the FDA says it could cause liver damage

‘Hopefully it stands up — because otherwise, we’re kind of all owed an explanation for why this was pushed on us’

The FDA issued a warning to consumers about potential health effects from CBD, including liver damage.
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Brandon Warne, a Minnesota Twins beat reporter for the sports news outlet Zone Coverage, started taking cannabidiol (CBD) in August after growing increasingly frustrated with his depression and anxiety medications over the past four years.

“I was just at a point where nothing was working for me,” Warne, 33, of Minnesota’s Twin Cities area, told MarketWatch. “I was just trying to branch out because I was just so upset [and] distraught with my lack of progress towards mental health.”

Under the guidance of his psychiatrist and therapist, Warne started taking CBD and pared down his medication list. He tapered off the antidepressants bupropion GSK, -0.38% and Effexor PFE, +1.35% , but continued to take his anti-anxiety medication, buspirone TEVA, -1.36% , after experiencing “wicked side effects” from trying to go off of it. He now takes CBD in the form of a 0.5-ml dose of Clean Remedies full-spectrum hemp extract oil every morning, and plans to eventually try to taper the buspirone as well.

Warne, who received his diagnoses after his grandfather’s death, wonders whether he was misdiagnosed. But the results he has seen since taking CBD, he said, have been “moderately positive.” “I’ve been feeling great since I got off my meds,” he said.

“ ‘We remain concerned that some people wrongly think that the myriad of CBD products on the market, many of which are illegal, have been evaluated by the FDA and determined to be safe, or that trying CBD ‘can’t hurt.’ ”

— — Amy Abernethy, FDA principal deputy commissioner

Warne isn’t entirely sure whether it’s the CBD oil or being off his meds that’s causing the improvement, but he is willing to continue trying CBD when he’s done with his current bottle. He said he still has “research” to do on the matter — and a new FDA warning backs him up.

The Food and Drug Administration said late Monday that what you don’t know about CBD might hurt you and warned that it could cause serious health problems, including liver damage.

The warning comes as millions of consumers have jumped on board with the non-psychoactive cannabis compound for reasons relating to health, wellness and recreation, and CBD has popped up on restaurant menus, in post-workout salves and in bath bombs.

The FDA sent letters warning 15 companies for illegally selling CBD-containing products. The federal agency also updated its position to clarify that the substance increasingly infused in pills, lotions, food products and wellness beverages “has the potential to harm you, and harm can happen even before you become aware of it.”

“We remain concerned that some people wrongly think that the myriad of CBD products on the market, many of which are illegal, have been evaluated by the FDA and determined to be safe, or that trying CBD ‘can’t hurt,’” Amy Abernethy, the FDA’s principal deputy commissioner, said in a statement.

The only CBD product approved by the FDA is the prescription drug Epidiolex, which treats pediatric epilepsy. It’s illegal to market CBD as a dietary supplement.

The compound can cause liver injury, interact with other drugs, and increase the risk of drowsiness and sedation when used with alcohol, the FDA said. Studies using lab animals have also shown negative impacts on the male reproductive system, though the takeaway for human patients remains unclear, the FDA said.

The agency also provided a list of potential side effects related to CBD, including sleepiness, diarrhea and/or a decrease in appetite, and mood changes such as agitation and irritability.

Many questions, not many answers

Scientists still don’t know what happens if a person consumes CBD daily for sustained time periods; the compound’s effect on children who take CBD, growing fetuses or breastfed newborns; its interactions with herbs and botanicals; and whether it leads to the same male reproductive problems in men as observed in animals, the FDA said.

What’s more, the FDA is concerned about “a lack of appropriate processing controls and practices”: Many products tested by the FDA have contained different CBD levels than what manufacturers claimed, and there have been reports of products containing unsafe levels of pesticides, heavy metals and THC, the agency said.

“I still don’t think it’s so harmful that I shouldn’t use what I have,” Warne said in response to the new FDA warning. “But it certainly makes me question how settled the science is … and maybe it’s not as ironclad as I thought it was before.”

64 million Americans have tried CBD

Research published this year by the consumer-data firm MRI-Simmons estimated that 3.7 million U.S. adults were CBD consumers, with a median age of 45. Even more appear to have dabbled in the substance: Some 64 million Americans — 26% of the country — report having tried CBD in the last two years, according to a nationally representative Consumer Reports survey of more than 4,000 people conducted in January. One in seven of those respondents reported daily use.

And many CBD users use the compound for its health potential, though their outcomes tend to be mixed.

More than a third of respondents to the Consumer Reports survey said they used CBD to reduce stress or anxiety or promote relaxation; 63% of those people said the compound was “extremely or very effective” at doing so, while 16% said it was not at all or only slightly effective. Nearly one in four respondents said they used CBD to help with joint pain, with 38% calling it “extremely or very effective” and 27% saying it was slightly or not at all effective.

The Mayo Clinic says that “although some research appears to indicate that CBD might hold benefit for treating anxiety-related disorders, more study is needed.” And physician Peter Grinspoon, writing on the Harvard Health Blog, noted that an animal study had shown that applying CBD to the skin could help lower arthritis-related pain and inflammation. “More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control,” he added.

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Warne is not alone in using CBD to replace or supplement a medication: 30% of respondents to the Consumer Reports survey said they had taken CBD in addition to a prescription or over-the-counter medication, while 22% said they replaced the medication with CBD entirely. A third of those who replaced a medication with CBD said that the drug was a prescription anti-anxiety drug.

Still, Warne called the FDA’s words of caution “prudent” and agreed that more research should be conducted on CBD’s benefits and risks.

“Hopefully it stands up — because otherwise, we’re kind of all owed an explanation for why this was pushed on us for the past year or however long this has been popular,” he said. “Hopefully we get an explanation one way or the other.”

CBD & Liver Damage: Learn If CBD Can Actually Affect Liver Functions!

Studies show a higher prevalence of liver cirrhosis or liver damage in the United States of America than before. It is an important health concern and a significant reason for morbidity and mortality.

Due to the prevalence of liver damage, the use of CBD oil has grown in popularity across the United States. The public has become more aware of the health benefits and the possible adverse effects of CBD usage.

Can CBD Cause Liver Damage?

CBD oil has a low risk of side effects, thus. Researchers used daily doses of 1,500 mg to 3,000 mg CBD to examine the safety and effectiveness of CBD in humans. A sample group took a dose of 1,500 mg of CBD for six weeks; scientists identified no life-threatening negative effects.

Recent research on mice in 2019 found that increased dosages of CBD can harm the liver, garnering significant media coverage. The study also caught the attention of people who have been seeking a major side effect to disprove CBD’s therapeutic potential. Like every other medicine, CBD does have its side effects, but the real question is if it is harmful to liver function when taken in an average dose.

  • Effect Of CBD On The Liver Of Mice

The University of Arkansas conducted research on a group of 8-week-old mice to study the treatment of various dosages of CBD. The research had a problem: there were not enough extensive toxicological studies on CBD safety. It was crucial to establish the effects since companies continue to market CBD and CBD-derived goods.

Likewise, when scientists give mice repeated doses of a lower concentration of CBD (50 mg), it results in liver damage and edema. Due to the difference in the physiology of humans and mice, the size of the liver is one of the many aspects that they must consider. When analyzing the benefits of CBD in human beings, it is vital to know how far these differences fare.

According to previous studies, CBD products, when prescribed to adults, resulted in elevated liver tests. Hence, scientists conducted a study to compare the occurrence of higher liver tests in an adult population who self-administer CBD to the average and general adult population.

Studies concluded that people who self-administer CBD for various ailments did not appear to have increased results in their liver tests. However, the underlying diseases or medicines taken to treat these conditions could be the main source of the anomalies. Self-medication of CBD, when taken in controlled amounts, was not linked to clinical liver damage in adults.

Is CBD Good For Fatty Liver?

All mammals have an endocannabinoid system consisting of (CB1 and CB2) receptors. CBD interacts with ECS and helps in mood, appetite, sleep, and memory regulation. The body naturally produces endocannabinoids. These molecules bind to the C1 and C2 receptors, found in the central and peripheral nervous systems, respectively.

The body’s ability to stabilize and adapt happens in the ECS. The ECS controls homeostasis to maintain balance. Moreover, this network regulates the equilibrium of the body’s many systems and organs, including the liver.

When the liver gets injured, inflamed, or malfunctions, the body’s response is to produce more endocannabinoids. The ECS’s activity is mainly associated with a healthy liver. In fact, the ECS components in the liver are low in concentration.

Emerging evidence indicates that cannabinoids play a key role in fatty liver regulation. They are mediated by cannabinoid receptor activation.

While researchers are still looking into how CBD interacts with the ECS, most results are mainly based on assumptions. But they believe that the endocannabinoids take time to break down. Hence, it enhances the functions of these neuroreceptors in the body.

Can CBD Oil Help People With Liver Cancer?

Studies about cannabis and its efficacy in liver cancer reveal that it can deter tumor cells from spreading. Moreover, scientists revealed that it could destroy cancer cells while preserving healthy cells. CBD Oil is used in various ways to help fight liver cancer and prevent cancer growth. First, it acts as an anti-metastatic agent, inhibiting the development of reserved tumor masses in the liver. Second, it inhibits the growth of new blood vessels, which aid cancer progression.

CBD causes pre-programmed cell death. Scientists discovered this ability while studying the effects of CBD in animals. These anti-cancer features apply to both CBD and THC.

Cannabidiol For Viral Hepatitis

Viral hepatitis B (HBV) and hepatitis C (HCV) are grave public health concerns worldwide. Both viruses induce severe liver damage if left untreated, resulting in cirrhosis and cancer. Unlike HBV, which has a vaccination, HCV does not. The potential of drug resistance and the high cost of existing medicines led to the discovery and development of cost-effective medications.

With the recent spike in interest in medical cannabis CBD, scientists kept pushing to discover more of its benefits. Researchers are looking into analyzing and verifying the therapeutic potential of CBD liver function.

They found CBD to limit the multiplication of the hepatitis C virus by nearly 90% in a study published in the Journal of Pharmacognosy Research. They concluded from this research that CBD has the potential to be further researched as a treatment for viral hepatitis. Moreover, people can use it as a combination therapy with existing medications.

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CBD For Hepatic Ischemia

Hepatic ischemia is a prevalent complication of liver surgery and transplant. It causes the liver to be severely inflamed and can even lead to transplant and rejection-related mortality. Moreover, oxidative stress can aggravate the patient’s condition.

Scientists found that CBD has antioxidative properties. Further, it also has anti-inflammatory effects. Thus, it could help to reduce inflammation and protect the liver from oxidative damage. Researchers found that CBD efficiently reduced inflammation and oxidative stress during experiments in labs. Not only that, but it also caused an increase in malignant cell death in the liver. According to other studies, when scientists treated rats with hepatic ischemia with CBD, it resulted in a considerable reduction in liver damage.

CBD For Liver Encephalopathy

Hepatic encephalopathy is defined by psychological disturbances that occur due to liver malfunction. Personality changes, confusion, and movement issues are just a few signs. In severe circumstances, it can lead to a coma.

This condition is usually caused by inflammation. Scientists conducted a study on mice with hepatic encephalopathy to determine the therapeutic effects of CBD oil. They found that CBD oil restored neurological function and cognitive capabilities. CBD also helps restore liver function and regulates the overall level of liver enzymes by lowering ammonia levels in the blood.

CBD For Autoimmune Hepatitis

Inflammation of the liver causes autoimmune hepatitis to an already compromised immune system. The TRP (transient receptor potential) is a set of membrane proteins involved in transmitting various chemical and physical signals.

Studies report that when TRPV1 is activated, it lowers the inflammation of the liver by activating myeloid-derived suppressor cells (MDSCs). Hence, blocking the inflammation leads to autoimmune hepatitis.

According to research, CBD causes the TRPV1 receptor to activate. Not only that, but it also helps in reducing inflammation and pain due to the proliferation of T cells. It is safe to say that CBD can help prevent and treat autoimmune hepatitis.

Hemp For Alcohol-Induced Liver Fibrosis

Liver fibrosis happens due to constant liver damage caused by overconsumption of alcohol. Chronic alcohol abuse eventually leads to liver cirrhosis.

Scientists found that CBD has anti-fibrosis characteristics. It hinders the production of collagen by cells that cause fibrosis. Moreover, it can also help to counteract the effects of alcohol-induced liver damage.

Does CBD Oil Affect Liver Enzymes?

There have been conflicting results of studies on CBD oil’s effect on liver function. According to one study, 10% of the participants had increased levels of liver enzymes and had to quit using CBD as a result. Scientists found that CBD improves liver function in other trials. To avoid any possible CBD-drug interactions and minimize liver stress, individuals with liver disorders should limit their use of over-the-counter (OTC) drugs. If the individual does not exceed a dose of 20 mg CBD/kg/day, CBD is typically safe for liver function.

Dosage Of CBD For Correct Liver Functioning

There is no right amount of dosage when it comes to CBD and liver. Most human medical trials that suggested precise CBD dosages have been conducted on anxiety, chronic disorders including epilepsy, and multiple sclerosis models. There is yet to be a clinical investigation that looks into CBD’s effects on various stages of liver diseases. Moreover, researchers have yet to determine a proper dosage for this condition.

The ideal dosage of CBD for each person is defined by several factors: weight, age, and gender. Moreover, you also have to consider the intensity of the symptoms, one’s metabolic rate, and experience with CBD products.

The best method is, to begin with a minimal dose and slowly increase it until you achieve the desired relief. We suggest starting with 5 to 10 mg of CBD and evaluating the results for one week. If you believe the amount is inadequate, you can increase the dose to 5 mg and continue for another week, reevaluating the outcomes.

It would be best to ask a physician to measure the most suitable dosage range for you. Also, they should assist you in avoiding possible drug interactions if you are using medication.

Benefits And Side Effects Of Hemp For Liver

CBD can help reduce feelings of anxiety and sadness, control PTSD symptoms, and ease chronic pain. Moreover, it offers protection against some neurological disorders. General enhanced brain, heart, and healthy skin are possible CBD oil advantages. However, researchers need to conduct more studies to figure out how CBD affects these ailments.

On the other hand, the evidence from consumers that the benefits of CBD are many. Further, CBD may provide these benefits without the euphoric symptoms associated with marijuana. Even though some CBD products contain trace levels of THC, these amounts are trivial compared to the amount required to feel high.

CBD oil may be a helpful approach to improving your quality of life. If you are looking for a way to relax after a hectic day at work, CBD may relieve that stress. If you seek treatment for chronic pain and muscle spasms, CBD may help reduce the sensation.

Negative Effects Of CBD

CBD offers a high level of safety. People turn to CBD as a low-risk alternative to traditional liver disease treatment methods. But, when ingested in excessive dosages, it causes a few side effects, including:

  • Dizziness
  • Gastrointestinal problems
  • Fatigue
  • Dry mouth
  • Appetite changes

Some of these adverse effects may occur due to an overdose. Also, ingesting an incorrectly labeled product with more than 0.3% THC can cause such side effects. Lastly, if one obtains CBD from low-quality hemp or is processed with harsh solvents, one will suffer from adverse reactions. When taking high-quality CBD oil daily, the mentioned adverse effects are almost non-existent.

Best CBD Oil For Liver Issues

#1. Flavored Hemp Oil By BudPop

BudPop offers two varieties of CBD oil that include peppermint tincture and natural CBD. The tincture comes in a 1 fl oz glass dropper bottle. Each bottle contains 1,500 mg of CBD and 50 mg of CBD per serving. Further, ingestion is simple because all you need to do is place a few drops of the product under your tongue.

The tincture contains no synthetic compounds or preservatives. It is organically flavored with peppermint and has been lab certified for purity and strength. The tincture is composed of CBD from organic hemp, natural peppermint oil, terpenes, sucralose, and water. Each bottle contains 30 servings which can last you a month or more depending on usage.

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BudPop CBD uses hemp farmed in the United States. Both peppermint and natural CBD tinctures contain natural terpenes for that smooth and rich taste. You can use the dropper to measure the amount of oil. Drop the oil under your tongue and hold it for at least 20 seconds. It may take some time for the oil to take effect, and when it does, you may experience a pleasant and soothing calm. You can also change the dose by ingesting a different quantity of drops.

BudPop recommends keeping the tincture in a cool, dry place away from sunlight. They back their products with a 30-day money-back guarantee. Hence, you can return them if you feel that the product is not working for you. However, they only allow returns for unopened products.

#2. Full-Spectrum CBD Oil By Exhale Wellness

Exhale Wellness offers a full-spectrum CBD oil. Its oils are non-GMO, free from preservatives, organic, and made of 100% natural ingredients. Exhale Wellness’s full-spectrum CBD oil comes in a clean glass dropper bottle, and it is available in 600 mg and 1,200 mg. Exhale Wellness offers premium hemp products that are lab tested for accuracy and derived from legal complaint hemp. All products are not tested on animals and are cruelty-free. Exhale Wellness offers a 30-day money-back guarantee and 20% off on the first purchase.

How To Consume CBD Tinctures

Most manufacturers sell CBD oils in 30 ml glass dropper vials, which contain around 30 doses of CBD. You can prolong the shelf life by keeping it in a dry, cold, and dark environment away from light. Many CBD users agree that consuming a tincture is one of the simplest techniques to ingest CBD oil due to its easy packing. You only need a few drops sublingually and wait for them to work.

The best method for ingesting CBD oil is sublingual. Hold the oil below your tongue for at least 20 seconds before taking your dose. While the oil is resting under your tongue, the CBD is absorbed by the thin mucus membranes. It avoids digestion and rapidly enters the circulatory system. Holding the oil under your tongue allows the oil to permeate your system quickly. You may feel the results sooner if you keep it under your tongue rather than ingest it.

However, some users may need extra time to select their ideal dosage, and some users may dislike the taste of oils. The natural bitterness of hemp compounds most likely causes it. That is why many companies use various flavors to cover the taste of hemp. Some consumers also report a burning or tingling sensation while using the oil. While this is not hazardous, it may cause CBD users to seek out different methods of consuming the product.

FAQs: CBD Oil & Liver Functioning

#1. How Long Would It Take For CBD Oil To Work?

Several factors determine the time consumed for CBD oil to work. Because everyone is different, an individual’s biology can influence, to some extent, how long it takes for CBD oil to take its optimum effect. You must consider the person’s metabolic rate, age, fitness level, and tolerance.

First, hold the CBD oil under your tongue to allow the oil to enter your mucous membranes. It may take approximately half an hour to know the effect of CBD oil in this manner. It is one of the easiest ways to experience the benefits of CBD oil.

Then there is the alternative of simply swallowing the CBD oil or mixing it with food or drink. You can take it along with your food or drink instead of using it sublingually, but you will have to wait for the effects to kick in. It is totally up to you to decide how to use CBD oil based on your preferences and needs.

#2. Why Should We Use CBD Tinctures?

CBD tinctures can be effective in a variety of ways. CBD products may be pretty efficient at relieving pain in the body. The ECS system is a unique mechanism in the human body. It helps the body govern many functions and activate specific immunological responses. Moreover, this system regulates bodily activities like eating, pain sensation, and sleep.

#3. Isolate, Broad-Spectrum, And Full-Spectrum CBD Oil – What Is Their Difference?

Full-spectrum CBD contains all of the components present in hemp plants, including THC, the chemical that causes a high. In broad-spectrum CBD, the hemp plant includes a number of components, including CBD, but no THC. While you will still receive many benefits, they will be less intense owing to the lack of THC. Isolate CBD is the purest form of CBD. It is purely made of CBD, and no other compounds are present.

#4. What Are The Benefits Of Buying BudPop CBD Oil?

BudPop uses hemp grown in the USA. The hemp used in their oils is organic and free from toxins and heavy metals. The BudPop CBD tinctures are available in two flavors. It is potent and contains legal amounts of THC. Moreover, BudPop offers Certificates of Analysis for its goods, including detailed information regarding their effectiveness, durability, and purity. BudPop provides quick and easy shipping; they will pack and ship your orders immediately and at no extra expense.

Final Thoughts: Does CBD Prevent Liver Illnesses?

Research has shown that CBD effectively treats various severe liver illnesses, including fatty liver disease, liver cancer, fibrosis, and cirrhosis. High-quality CBD oils offer lots of benefits. Its effectiveness may be therapeutic in various ailments involving liver malfunction. Moreover, it may help to substitute long-term use of certain drugs. A high dosage can cause liver toxicity. Hence, we advise patients to seek medical advice before introducing CBD into their lifestyle. Discuss the dosage and set the best time timetable to avoid probable drug interactions.

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