Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer’s Disease This is a randomized, double-blinded, placebo-controlled, crossover trial that aims to 1) determine the efficacy of 14 Best CBD Oils for Dementia
Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer’s Disease
This is a randomized, double-blinded, placebo-controlled, crossover trial that aims to 1) determine the efficacy of THC-free cannabidiol (CBD oil) in reducing the severity of agitation among participants and 2) determine whether THC-free CBD oil can reduce the burden on caregivers and increase the participants’ quality of life.
|Condition or disease||Intervention/treatment||Phase|
|Alzheimer Disease Dementia Major Neurocognitive Disorder With Aggressive Behavior||Drug: THC-free CBD Oil Drug: Placebo||Phase 2|
Individuals with Alzheimer’s and other forms of dementia often go through a period of significant behavioral and psychological symptoms of dementia (BPSD). It is estimated that up to 90% of persons with dementia (PWD) experience behavior problems at some point. BPSDs can be challenging for both unpaid family caregivers as well as paid caregivers. Family caregivers provide the bulk of care for PWD and number over 15 million. One of the most common types of BPSDs is agitation with a prevalence of up to 87%, based on a recent systematic review. Agitation can lead to impaired daily functioning, prolongation of hospitalization, reduced time to institutionalization, and is associated with higher mortality. Additionally, agitated behavior is associated with increased injury to both patients and caregivers. Based on the 2018 Alzheimer’s disease drug development pipeline report almost 70% of clinical trials related to BPSD are dedicated to agitation behavior. Finding ways to address agitation is necessary to improve overall quality of life for PWD and their caregivers. Currently, there are no medications available specifically for the treatment of BPSDs. The use of benzodiazepines, antipsychotics and mood stabilizing agents are common, but the risks and side effects often outweigh any benefits.
Several small studies have investigated the use of cannabinoids in the treatment of pathology and symptomology of Alzheimer’s disease (AD), as well as treatment of the agitation component of BPSD. A handful of these studies showed that the symptoms of BPSD were decreased with the use of cannabinoids. However, due to small sample sizes, study design, and short trial duration of these studies, the efficacy of these agents on BPSD cannot be confirmed. In addition, cannabinoids have demonstrated anti-oxidant and anti-inflammatory effects, and both processes have been indicated as major contributors to the neurologic effects of AD. Some evidence exists that agitation is related to this neuroinflammatory process. This study will examine the effects of cannabinoids on the behavioral and psychological symptoms of individuals with a dementia diagnosis.
14 Best CBD Oils for Dementia
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Discover Magazine’s Best CBD Oil For Dementia: PenguinCBD
Dementia is a condition that is as painful for the sufferer as it is for everyone around him or her. Before we start, it should be stressed that currently there is no cure for the ravages of dementia. However, there are many promising treatments on the horizon, both with regards to treating the underlying condition, and in easing the many symptoms it brings forth.
Since we are left with precious little in the way of traditional medicine to help the suffers find some relief from the condition, it has become the role of alternative therapeutics to help bring some comfort to those battling these conditions. CBD is rapidly becoming one of the favored treatments for dealing with many of the side effects brought on by dementia, even though it doesn’t treat the underlying condition. Here are some of the ways it can help improve the lives of those dealing with dementia.
Anxiety is one of the most common symptoms people with dementia face as the condition sets in. CBD oil, when used directly and in a wide variety of foods and drinks, has been shown to help deal with anxiety for anyone using it. It is a common home remedy used for those dealing with both acute and chronic anxiety, often bringing relief when more traditional medications have failed to have a noticeable impact.
In fact, many members of our team use CBD oil to treat anxiety generally. It is a simple remedy that is highly portable, making it easy to stick in a pocket or bag and pull out whenever needed. A dose can be easily measured out, added to our favorite food and drink, and consumed within seconds.
This is an important point when working with those living with dementia. They may develop problems taking pills, or have a general animosity to medicines at large, but will gladly drink their favorite cup of tea. All the caregiver needs to do is measure in a dose and mix it thoroughly. The recipient doesn’t have to know, and in just a matter of minutes will be experiencing the relaxing properties of CBD without having to worry about any of the nasty side effects that can come with traditional treatments.
Depression is among the most common comorbidities for many forms of dementia. For good reason, since depression is usually the result of reduced/negatively impacted functioning of the brain. When it is literally damaging itself, some form of depression shouldn’t be unexpected. The one thing that has surprised many researchers and medical professionals is the dangers inherent in treating dementia-related depression with traditional medications.
Many treatments have been found to cause extreme side effects, up to and including death. As such, treating depression in many cases turns out to be a palliative measure rather than focusing on the condition itself.
Now, it is important to note that we aren’t doctors. Our team of reviewers does not claim to be medical professionals. Always check with the doctor before making any decisions that will impact the life and wellbeing of your loved one.
CBD oil has been shown in many studies to help treat mild to moderate depression, even in cases where traditional treatments have failed. The reasons for this are complex, though they revolve around how CBD interacts with the nervous system while simultaneously treating causes of depression, such as anxiety and inflammation.
It does this without the risk of side effects or the painful risk of addiction, making it a powerful tool to consider using when treating dementia-related depression. Many members of our team of product reviewers have moderate depression (caused by the winter months, not the work environment!) As such, we took home several bottles of CBD oil and tried them out. During our testing period we were pleased to report that our symptoms decreased by a significant margin. Now, to be fair, we also did things like try to get better sleep and exercise more, which have also been shown to help deal with the symptoms of depression. But the results speak for themselves.
Here are fourteen of the best CBD oils we have found available. Each of them is made by reputable companies that take the time needed to craft an amazing experience for its consumers. Beyond that, we found three companies that stand out as being amongst the best in the field:
1. Penguin CBD
Start enjoying life by grabbing a couple of CBD oil from one of the best producers of CBD products in the United States. This oil is perfect for helping you relax, soothe away pain, and banish anxiety. It is made with the purest CBD isolate available, sourced from non-GMO hemp grown from seed at the best farms in Oregon.
This oil is guaranteed to be filled to the rim with the CBD goodness you want and crave, without any unwanted additives that can lead to an inferior product. One such problematic ingredient you can rest assured is not in this CBD oil is THC. You will not have to worry about experiencing an unwanted high, something that can’t be said for other brands’ oils.
2. Everest CBD
Are you looking for a delicious CBD oil that is truly full-spectrum? Everest offers you the opportunity to embrace the powers of CBD compounds in order to help you start living your best possible life. Everest is one of the leaders in the American CBD market, starting shortly after industrial hemp farming was legalized back in 2004. Since then, they have worked tirelessly to craft amazing products designed to bring the power of the hemp plant to as many people as possible.
The production process starts with sourcing only the highest quality non-GMO seed stock, growing it in carefully tended fields located here in the United States, and then harvesting it using the latest technology. The end result is a CBD product that can help you deal with pain, anxiety, and depression without missing a beat. All you have to do is measure a dose and see what it can do for you and your loved one.
3. Verma Farms
Verma Farms’ oil has been carefully designed from the ground up to provide you with the best experience possible. All you need to do is pick out the flavor that speaks to you and start living your best life.
Verma Farms has a long and storied history of producing quality CBD products, perfect for tackling everything from smoking cessation and weight loss to depression and anxiety. It is used by thousands of people every day, enabling them to quickly and easily tackle even the greatest challenge that life before them. Our team of happy product reviewers always keeps a bottle on hand, ready for those precious moments when we can fully relax and stop having to worry about the world for a few minutes.
4. R+R Medicinals
R+R Medicinals is one of the fastest growing CBD brands in the United States, and has finally brought what everyone has been looking for: USDA Organic, reasonably priced, high performance products. Their employee and veteran-owned company truly has the customer at heart – there is always a live person there to answer questions or help any customer with questions! They’re truly doing it right in a sea of other brands.
5. MedTerra CBD Oil
MedTerra has earned a reputation for excellence in the CBD community due to its dedication to providing the best possible CBD products to users throughout the United States. We were particularly impressed with the varieties MedTerra offered, focusing on everything from sleeping to keeping calm in the face of even the most stressful of situations.
Our team of reviewers was pleased with how the CBD products made us feel. We were better able to relax and focus on the task at hand, making it easier to achieve our goals with ease. The CBD oil really did help us narrow in on the truly important things in life by taking away the doubts, pain, and anxiety that tend to fill our minds on a daily basis. We were pleased with the result and full-heartedly recommend this brand to anyone looking for quality CBD products from a developer with a long history in the market.
6. Just CBD Oil
Are you looking to explore the world of CBD but don’t want to have to worry about the often bitter taste of hemp? Just CBD has your back with a CBD oil that is made with 100% natural and refined CBD isolate, a process that strips out everything but the CBD compounds from the all-natural industrial hemp plant.
Produced by a titan in the CBD world, this CBD oil has been carefully designed to meet the highest quality standards possible. Each bottle is GMP-certified and party lab tested – meaning you are guaranteed to have the best possible experience when using this product.
Our team of reviewers was delighted to try these out for a couple of weeks. We had a variety of goals in mind, ranging from the standard relaxation to help us lose weight or stop smoking. It helped all of us meet our goals, without breaking a sweat.
7. CBDfx Oil
CBDfx is one of the leading companies in the CBD world, among the first to offer CBD products to consumers nationwide. They have taken their early successes and built their practice to offer a wide range of CBD products ranging from simple oils to complex gummies designed to replace multivitamins and diet aids. Our team has had plenty of experience with this brand, often holding it up as a standard-bearer when evaluating newcomers to the CBD marketplace.
During our many encounters, we have found that this company has taken the time and energy needed to produce a high-quality product that is guaranteed to help you deal with the challenges in your life, whether it be smoking cessation, losing weight, or simply relaxing after a long day at the office.
8. Five Full Spectrum CBD+THC Oil
Looking for a CBD+THC oil from a company dedicated to providing you with the best possible CBD and THC experience? Five is proud to offer customers around the nation (except for those that can’t legally purchase THC-inclusive products) with the opportunity to embrace the health benefits of CBD without having to sacrifice the calm and good feelings that come with using THC.
This product line has been carefully developed to provide those seeing the benefits of the full cannabis plant without dealing with the social stigma/potential legal headaches of using marijuana. Designed from the ground up to make finding the right dose easy, all you have to do is follow the directions and within minutes you will be feeling the bliss that can only come from THC. Our team of expert reviewers was amazed with the taste, affordability, and ease of use that came with this product. As such, we strongly recommend it if you happen to be in a state where such a purchase is legal.
9. Charlotte’s Web Oil
Charlotte’s Web has been in the CBD field since its inception, providing clients from around the United States with access to high-quality CBD products at affordable prices. Their main selling point, and one we at the office fully appreciated while evaluating their products, is the sheer volume of dosage sizes available. You are able to find the right dosage for you without having to spend countless hours carefully measuring. All you need to do is follow the directions on the bottle.
Tired of not knowing which CBD oil to buy to help you tackle your personal goals? cbdMD is delighted to offer you the opportunity to experience the many health benefits of hemp with none of the unwanted highs and side effects that come from using marijuana. Each easily affordable bottle comes packed to the gills with the finest full-spectrum CBD oils available, making this a surefire hit for anyone looking to soothe pain, calm anxieties, and relax after a long day.
11. Green Roads CBD Oil
One review of this brand of CBD Oil was quite apt: “The sense of calm just settles over you. It’s like a switch…” And this has played out in our review of this brand. It is among the fastest working CBD oil products available on the market, regardless of the dose. It must be because of the company’s dedication to providing a holistic product that brings to you every good bit of the hemp plant.
Our team was pleased with the variety of products available, both in regards to the dosage and the flavors. It was a joy selecting different varieties to test out during our customary two-week period. During that time we found that this brand of CBD, like the rest we have tested, was able to help us embrace life and tackle the challenges in front of us. As the reviewer said, it was like a switch.
12. Royal CBD Oil
Royal CBD has worked tirelessly to provide you with the best possible CBD oil. All you need to do is read the jar to find out the right dose for you and off you go to a world of bliss. Our review of this brand showed that it did everything it promised and more.
During our review, we were glad to notice that the office became a friendlier, more relaxed place as everyone collectively chilled out thanks to the calming power of CBD. It was a truly marvelous fortnight, and we recommend that you give this brand a try.
13. Cornbread Full Spectrum CBD Oil
Cornbread offers you a wide range of CBD products, including gummies and full-spectrum CBD oil. Their products have one unique advantage that most manufacturers cannot match: The company produces its oil using only the flowers from the hemp plant. This results in a product that includes up to 2 mg of THC per serving in addition to all of the goodness that comes from using all-natural CBD.
Sadly, this means that this product is not available nationwide. It is only available in states that legalize the sale of products containing THC. As such, we strongly recommend that you look up your local laws before making a purchase. If it is available to you, we wholeheartedly recommend this brand and guarantee that you will be amazed by how it can help you achieve your life goals.
14. Gold Bee CBD Oil
Gold Bee has worked tirelessly to produce quality CBD products for use by people throughout the United States. Its goal was to produce a line of products perfect for nearly any event – be it relaxing after a long day at work or fighting off that cigarette craving. Our team of dedicated reviewers, by now CBD product specialists, found that Gold Bee’s products did help in keeping us calm and focused on our goal.
Bonus: Exhale CBD Oil
There is taking a break from work and then there is taking a moment to enjoy the power of CBD from the comfort of your desk. Exhale offers a nearly THC-free oil that has been carefully designed to make it easy for you to tackle any challenge in your way. All you have to do is pick a dose, enjoy, and watch as the worries of the world fall from your shoulders.
Made with 100% full spectrum CBD, this is the perfect oil for anyone looking to embrace all of the health benefits that come with CBD products without having to worry about any unwanted ingredients. Every bottle comes packed to the gills with a healthy dose of CBD, enough to help you do everything from stopping smoking to help lose those extra pounds you put on last winter. Our team of dedicated reviewers loved this brand, and so will you!